Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation

Glutamine has been implicated as an immunomodulatory nutrient, but how glutamine uptake is mediated during T-cell activation is poorly understood. We have shown that naïve T-cell activation is coupled with rapid glutamine uptake, which depended on the amino acid transporter ASCT2. ASCT2 deficiency i...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Nakaya, Mako, Xiao, Yichuan, Zhou, Xiaofei, Chang, Jae-Hoon, Chang, Mikyoung, Cheng, Xuhong, Blonska, Marzenna, Lin, Xin, Sun, Shao-Cong
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074507/
https://ncbi.nlm.nih.gov/pubmed/24792914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.04.007
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker