Synthesis and evaluation of 2-(18)F-fluoro-5-iodo-3-[2-(S)-3,4-dehydropyrrolinylmethoxy]pyridine ((18)F-Niofene) as a potential imaging agent for nicotinic α4β2 receptors

Nicotinic α4β2 acetylcholine receptors (nAChRs) have been implicated in various pathophysiologies including neurodegenerative diseases. Currently, 2-(18)F-A85380 (2-FA) and 5-(123)I-A85380 (5-IA) are used separately in human PET and SPECT studies respectively and require >4-6 hours of scanning. W...

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Autori principali: Kuruvilla, Sharon A, Hillmer, Ansel T, Wooten, Dustin W, Patel, Ashna, Christian, Bradley T, Mukherjee, Jogeshwar
Natura: Artigo
Lingua:Inglês
Pubblicazione: e-Century Publishing Corporation 2014
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074501/
https://ncbi.nlm.nih.gov/pubmed/24982821
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