PET Imaging of α4β2* Nicotinic Acetylcholine Receptors: Quantitative Analysis of [(18)F]Nifene Kinetics in the Nonhuman Primate

[(18)F]Nifene is an α4β2* nicotinic acetylcholine receptor (nAChR) agonist PET radioligand developed to provide accelerated in vivo equilibrium compared to existing α4β2* radioligands. The goal of this work is to analyze the in vivo kinetic properties of [(18)F]nifene with both kinetic modeling and...

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Main Authors: Hillmer, Ansel T., Wooten, Dustin W., Slesarev, Maxim S., Ahlers, Elizabeth O., Barnhart, Todd E., Murali, Dhanabalan, Schneider, Mary L., Mukherjee, Jogeshwar, Christian, Bradley T.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580212/
https://ncbi.nlm.nih.gov/pubmed/22851633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.112.103846
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