Measuring α4β2* nicotinic acetylcholine receptor density in vivo with [(18)F]nifene PET in the nonhuman primate

[(18)F]Nifene is an agonist PET radioligand developed to image α4β2* nicotinic acetylcholine receptors (nAChRs). This work aims to quantify the receptor density (B(max)) of α4β2* nAChRs and the in vivo (apparent) dissociation constant (K(Dapp)) of [(18)F]nifene. Multiple-injection [(18)F]nifene expe...

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Bibliographische Detailangaben
Hauptverfasser: Hillmer, Ansel T, Wooten, Dustin W, Slesarev, Maxim S, Ahlers, Elizabeth O, Barnhart, Todd E, Schneider, Mary L, Mukherjee, Jogeshwar, Christian, Bradley T
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2013
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824181/
https://ncbi.nlm.nih.gov/pubmed/23942367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2013.136
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