Nicotinic α4β2 receptor imaging agents. Part IV. Synthesis and Biological Evaluation of 3-(2-(S)-3,4-dehydropyrrolinylmethoxy)-5-(3’-(18)F-Fluoropropyl)pyridine ((18)F-Nifrolene) using PET

Imaging agents for nicotinic α4β2 receptors in the brain have been underway for studying various CNS disorders. Previous studies from our laboratories have reported the successful development of agonist, (18)F-nifene. In attempts to develop potential antagonists, (18)F-nifrolidine and (18)F-nifzetid...

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Détails bibliographiques
Auteurs principaux: Pichika, Rama, Kuruvilla, Sharon A., Patel, Narmisha, Vu, Kenny, Sinha, Sangamitra, Easwaramoorthy, Balu, Narayanan, Tanjore K., Shi, Bingzhi, Christian, Bradley, Mukherjee, Jogeshwar
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514651/
https://ncbi.nlm.nih.gov/pubmed/23141552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2012.09.009
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