Nicotinic α4β2 receptor imaging agents. Part IV. Synthesis and Biological Evaluation of 3-(2-(S)-3,4-dehydropyrrolinylmethoxy)-5-(3’-(18)F-Fluoropropyl)pyridine ((18)F-Nifrolene) using PET

Imaging agents for nicotinic α4β2 receptors in the brain have been underway for studying various CNS disorders. Previous studies from our laboratories have reported the successful development of agonist, (18)F-nifene. In attempts to develop potential antagonists, (18)F-nifrolidine and (18)F-nifzetid...

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Main Authors: Pichika, Rama, Kuruvilla, Sharon A., Patel, Narmisha, Vu, Kenny, Sinha, Sangamitra, Easwaramoorthy, Balu, Narayanan, Tanjore K., Shi, Bingzhi, Christian, Bradley, Mukherjee, Jogeshwar
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514651/
https://ncbi.nlm.nih.gov/pubmed/23141552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2012.09.009
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