Parkin-mediated ubiquitination of mutant glucocerebrosidase leads to competition with its substrates PARIS and ARTS

BACKGROUND: Parkinson’s disease (PD) is a movement neurodegenerative disorder characterized by death of dopaminergic neurons in the substantia nigra pars compacta of the brain that leads to movement impairments including bradykinesia, resting tremor, postural instability and rigidity. Mutations in s...

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Bibliographic Details
Main Authors: Bendikov-Bar, Inna, Rapaport, Debora, Larisch, Sarit, Horowitz, Mia
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074407/
https://ncbi.nlm.nih.gov/pubmed/24935484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1172-9-86
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