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Rab5 activation promotes focal adhesion disassembly, migration and invasiveness in tumor cells

Migration and invasion are essential steps associated with tumor cell metastasis and increasing evidence points towards endosome trafficking being essential in this process. Indeed, the small GTPase Rab5, a crucial regulator of early endosome dynamics, promotes cell migration in vitro and in vivo. P...

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Detalhes bibliográficos
Main Authors: Mendoza, Pablo, Ortiz, Rina, Díaz, Jorge, Quest, Andrew F. G., Leyton, Lisette, Stupack, Dwayne, Torres, Vicente A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074302/
https://ncbi.nlm.nih.gov/pubmed/23813952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.119727
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