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Rab5 activation promotes focal adhesion disassembly, migration and invasiveness in tumor cells

Migration and invasion are essential steps associated with tumor cell metastasis and increasing evidence points towards endosome trafficking being essential in this process. Indeed, the small GTPase Rab5, a crucial regulator of early endosome dynamics, promotes cell migration in vitro and in vivo. P...

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Bibliografski detalji
Glavni autori: Mendoza, Pablo, Ortiz, Rina, Díaz, Jorge, Quest, Andrew F. G., Leyton, Lisette, Stupack, Dwayne, Torres, Vicente A.
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074302/
https://ncbi.nlm.nih.gov/pubmed/23813952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.119727
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