Non-muscle Mlck is required for β-catenin- and FoxO1-dependent downregulation of Cldn5 in IL-1β-mediated barrier dysfunction in brain endothelial cells

Aberrant elevation in the levels of the pro-inflammatory cytokine interleukin-1β (IL-1β) contributes to neuroinflammatory diseases. Blood–brain barrier (BBB) dysfunction is a hallmark phenotype of neuroinflammation. It is known that IL-1β directly induces BBB hyperpermeability but the mechanisms rem...

Full description

Saved in:
Bibliographic Details
Main Authors: Beard, Richard S., Haines, Ricci J., Wu, Kevin Y., Reynolds, Jason J., Davis, Stephanie M., Elliott, John E., Malinin, Nikolay L., Chatterjee, Victor, Cha, Byeong J., Wu, Mack H., Yuan, Sarah Y.
Format: Artigo
Language:Inglês
Published: The Company of Biologists 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074294/
https://ncbi.nlm.nih.gov/pubmed/24522189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.144550
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items