Non-muscle Mlck is required for β-catenin- and FoxO1-dependent downregulation of Cldn5 in IL-1β-mediated barrier dysfunction in brain endothelial cells

Aberrant elevation in the levels of the pro-inflammatory cytokine interleukin-1β (IL-1β) contributes to neuroinflammatory diseases. Blood–brain barrier (BBB) dysfunction is a hallmark phenotype of neuroinflammation. It is known that IL-1β directly induces BBB hyperpermeability but the mechanisms rem...

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Detalhes bibliográficos
Main Authors: Beard, Richard S., Haines, Ricci J., Wu, Kevin Y., Reynolds, Jason J., Davis, Stephanie M., Elliott, John E., Malinin, Nikolay L., Chatterjee, Victor, Cha, Byeong J., Wu, Mack H., Yuan, Sarah Y.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074294/
https://ncbi.nlm.nih.gov/pubmed/24522189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.144550
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