PRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex

Defining the role of epigenetic regulators in hematopoiesis has become critically important, as recurrent mutations or aberrant expression of these genes has been identified in both myeloid and lymphoid hematological malignancies. We found that PRMT4, a type I arginine methyltransferase, whose funct...

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Bibliografiska uppgifter
Huvudupphovsmän: Vu, Ly P., Perna, Fabiana, Wang, Lan, Voza, Francesca, Figueroa, Maria E., Tempst, Paul, Erdjument-Bromage, Hediye, Gao, Rui, Chen, Sisi, Paietta, Elisabeth, Deblasio, Tony, Melnick, Ari, Liu, Yan, Zhao, Xinyang, Nimer, Stephen D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073674/
https://ncbi.nlm.nih.gov/pubmed/24332853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.11.025
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