Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity

RUNX1/AML1 is required for the development of definitive hematopoiesis, and its activity is altered by mutations, deletions, and chromosome translocations in human acute leukemia. RUNX1 function can be regulated by post-translational modifications and protein–protein interactions. We show that RUNX1...

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Autors principals: Zhao, Xinyang, Jankovic, Vladimir, Gural, Alexander, Huang, Gang, Pardanani, Animesh, Menendez, Silvia, Zhang, Jin, Dunne, Richard, Xiao, Andrew, Erdjument-Bromage, Hediye, Allis, C. David, Tempst, Paul, Nimer, Stephen D.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2008
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2259033/
https://ncbi.nlm.nih.gov/pubmed/18316480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1632608
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