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Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity
RUNX1/AML1 is required for the development of definitive hematopoiesis, and its activity is altered by mutations, deletions, and chromosome translocations in human acute leukemia. RUNX1 function can be regulated by post-translational modifications and protein–protein interactions. We show that RUNX1...
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| Główni autorzy: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Cold Spring Harbor Laboratory Press
2008
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2259033/ https://ncbi.nlm.nih.gov/pubmed/18316480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1632608 |
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