PRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex

Defining the role of epigenetic regulators in hematopoiesis has become critically important, as recurrent mutations or aberrant expression of these genes has been identified in both myeloid and lymphoid hematological malignancies. We found that PRMT4, a type I arginine methyltransferase, whose funct...

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Main Authors: Vu, Ly P., Perna, Fabiana, Wang, Lan, Voza, Francesca, Figueroa, Maria E., Tempst, Paul, Erdjument-Bromage, Hediye, Gao, Rui, Chen, Sisi, Paietta, Elisabeth, Deblasio, Tony, Melnick, Ari, Liu, Yan, Zhao, Xinyang, Nimer, Stephen D.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073674/
https://ncbi.nlm.nih.gov/pubmed/24332853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.11.025
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