PRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex

Defining the role of epigenetic regulators in hematopoiesis has become critically important, as recurrent mutations or aberrant expression of these genes has been identified in both myeloid and lymphoid hematological malignancies. We found that PRMT4, a type I arginine methyltransferase, whose funct...

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Detalhes bibliográficos
Main Authors: Vu, Ly P., Perna, Fabiana, Wang, Lan, Voza, Francesca, Figueroa, Maria E., Tempst, Paul, Erdjument-Bromage, Hediye, Gao, Rui, Chen, Sisi, Paietta, Elisabeth, Deblasio, Tony, Melnick, Ari, Liu, Yan, Zhao, Xinyang, Nimer, Stephen D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073674/
https://ncbi.nlm.nih.gov/pubmed/24332853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.11.025
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