A serine cluster mediates BMAL-dependent CLOCK phosphorylation and degradation

Eitemau Tebyg

• Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1
  gan: Hu, Yan, et al.
  Cyhoeddwyd: (2011)
• BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system
  gan: Kondratov, Roman V., et al.
  Cyhoeddwyd: (2003)
• BMAL1 Shuttling Controls Transactivation and Degradation of the CLOCK/BMAL1 Heterodimer
  gan: Kwon, Ilmin, et al.
  Cyhoeddwyd: (2006)
• CK2α phosphorylates BMAL1 to regulate the mammalian clock
  gan: Tamaru, Teruya, et al.
  Cyhoeddwyd: (2009)
• Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex
  gan: Gorbacheva, Victoria Y., et al.
  Cyhoeddwyd: (2005)