Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex

The circadian clock controls many aspects of mammalian physiology, including responses to cancer therapy. We find that wild-type and circadian mutant mice demonstrate striking differences in their response to the anticancer drug cyclophosphamide (CY). While the sensitivity of wild-type mice varies g...

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Detalhes bibliográficos
Main Authors: Gorbacheva, Victoria Y., Kondratov, Roman V., Zhang, Renliang, Cherukuri, Srujana, Gudkov, Andrei V., Takahashi, Joseph S., Antoch, Marina P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC546637/
https://ncbi.nlm.nih.gov/pubmed/15689397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409897102
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