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Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock
Mice deficient in the circadian transcription factor BMAL1 (brain and muscle ARNT-like protein) have impaired circadian behavior and demonstrate loss of rhythmicity in the expression of target genes. Here we report that Bmal1(−/−) mice have reduced lifespans and display various symptoms of premature...
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| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Cold Spring Harbor Laboratory Press
2006
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1522083/ https://ncbi.nlm.nih.gov/pubmed/16847346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1432206 |
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