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Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock

Mice deficient in the circadian transcription factor BMAL1 (brain and muscle ARNT-like protein) have impaired circadian behavior and demonstrate loss of rhythmicity in the expression of target genes. Here we report that Bmal1(−/−) mice have reduced lifespans and display various symptoms of premature...

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Autori principali: Kondratov, Roman V., Kondratova, Anna A., Gorbacheva, Victoria Y., Vykhovanets, Olena V., Antoch, Marina P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1522083/
https://ncbi.nlm.nih.gov/pubmed/16847346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1432206
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