Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex

Eitemau Tebyg

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• Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock
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• Circadian Clock Genes as Modulators of Sensitivity to Genotoxic Stress
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• Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1
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• Pharmacological modulators of the circadian clock as potential therapeutic drugs: focus on genotoxic/anticancer therapy
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  Cyhoeddwyd: (2013)