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CK2α phosphorylates BMAL1 to regulate the mammalian clock
Clock proteins govern circadian physiology and their function is regulated by a variety of mechanisms. Here we demonstrate that CK2α phosphorylates the core circadian regulator BMAL1. Gene silencing of CK2α or mutation of the highly conserved CK2-phosphorylation site in BMAL, Ser90, result in impair...
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| Publicado no: | Nat Struct Mol Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6501789/ https://ncbi.nlm.nih.gov/pubmed/19330005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1578 |
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