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CK2α phosphorylates BMAL1 to regulate the mammalian clock

Clock proteins govern circadian physiology and their function is regulated by a variety of mechanisms. Here we demonstrate that CK2α phosphorylates the core circadian regulator BMAL1. Gene silencing of CK2α or mutation of the highly conserved CK2-phosphorylation site in BMAL, Ser90, result in impair...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Tamaru, Teruya, Hirayama, Jun, Isojima, Yasushi, Nagai, Katsuya, Norioka, Shigemi, Takamatsu, Ken, Sassone-Corsi, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6501789/
https://ncbi.nlm.nih.gov/pubmed/19330005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1578
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