TNFα and SOCS3 regulate IRS-1 to increase retinal endothelial cell apoptosis

Rates of diabetes are reaching epidemic levels. The key problem in both type 1 and type 2 diabetes is dysfunctional insulin signaling, either due to lack of production or due to impaired insulin sensitivity. A key feature of diabetic retinopathy in animal models is degenerate capillary formation. Th...

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Bibliographic Details
Main Authors: Jiang, Youde, Zhang, Qiuhua, Soderland, Carl, Steinle, Jena J.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073498/
https://ncbi.nlm.nih.gov/pubmed/22266116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2012.01.003
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