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IGFBP-3 inhibits TNF-α production and TNFR-2 signaling to protect against Retinal Endothelial Cell Apoptosis

In models of diabetic retinopathy, insulin-like growth factor binding protein-3 (IGFBP-3) protects against tumor necrosis factors-alpha (TNF-α)-mediated apoptosis of retinal microvascular endothelial cells (REC), but the underlying mechanisms are unclear. Our current findings suggest that at least t...

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Detalhes bibliográficos
Publicado no:Microvasc Res
Main Authors: Zhang, Qiuhua, Steinle, Jena J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4346193/
https://ncbi.nlm.nih.gov/pubmed/25086184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mvr.2014.07.009
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