Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutations

The leukocyte adhesion cascade is important in chronic lymphocytic leukemia (CLL), as it controls migration of malignant cells into the pro-survival lymph node microenvironment. Circulating trisomy 12 CLL cells have increased expression of the integrins CD11a and CD49d, as well as CD38, but the tiss...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Riches, John C., O’Donovan, Conor J., Kingdon, Sarah J., McClanahan, Fabienne, Clear, Andrew J., Neuberg, Donna S., Werner, Lillian, Croce, Carlo M., Ramsay, Alan G., Rassenti, Laura Z., Kipps, Thomas J., Gribben, John G.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society of Hematology 2014
الموضوعات:
Lymphoid Neoplasia
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073326/
https://ncbi.nlm.nih.gov/pubmed/24829201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-01-552307
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