Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutations

The leukocyte adhesion cascade is important in chronic lymphocytic leukemia (CLL), as it controls migration of malignant cells into the pro-survival lymph node microenvironment. Circulating trisomy 12 CLL cells have increased expression of the integrins CD11a and CD49d, as well as CD38, but the tiss...

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保存先:
書誌詳細
主要な著者: Riches, John C., O’Donovan, Conor J., Kingdon, Sarah J., McClanahan, Fabienne, Clear, Andrew J., Neuberg, Donna S., Werner, Lillian, Croce, Carlo M., Ramsay, Alan G., Rassenti, Laura Z., Kipps, Thomas J., Gribben, John G.
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2014
主題:
Lymphoid Neoplasia
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073326/
https://ncbi.nlm.nih.gov/pubmed/24829201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-01-552307
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