Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutations

The leukocyte adhesion cascade is important in chronic lymphocytic leukemia (CLL), as it controls migration of malignant cells into the pro-survival lymph node microenvironment. Circulating trisomy 12 CLL cells have increased expression of the integrins CD11a and CD49d, as well as CD38, but the tiss...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Riches, John C., O’Donovan, Conor J., Kingdon, Sarah J., McClanahan, Fabienne, Clear, Andrew J., Neuberg, Donna S., Werner, Lillian, Croce, Carlo M., Ramsay, Alan G., Rassenti, Laura Z., Kipps, Thomas J., Gribben, John G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2014
Gaiak:
Lymphoid Neoplasia
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073326/
https://ncbi.nlm.nih.gov/pubmed/24829201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-01-552307
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