PD-L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia

Blockade of the programmed cell death 1 (PD-1)/programmed death-ligand 1 (PD-L1) immune checkpoint augments antitumor immunity and induces durable responses in patients with solid cancers, but data on clinical efficacy in leukemias are sparse. Chronic lymphocytic leukemia (CLL) is associated with a...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: McClanahan, Fabienne, Hanna, Bola, Miller, Shaun, Clear, Andrew James, Lichter, Peter, Gribben, John G., Seiffert, Martina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497961/
https://ncbi.nlm.nih.gov/pubmed/25800048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-01-622936
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