PD-L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia

Blockade of the programmed cell death 1 (PD-1)/programmed death-ligand 1 (PD-L1) immune checkpoint augments antitumor immunity and induces durable responses in patients with solid cancers, but data on clinical efficacy in leukemias are sparse. Chronic lymphocytic leukemia (CLL) is associated with a...

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Bibliographische Detailangaben
Veröffentlicht in:Blood
Hauptverfasser: McClanahan, Fabienne, Hanna, Bola, Miller, Shaun, Clear, Andrew James, Lichter, Peter, Gribben, John G., Seiffert, Martina
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2015
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497961/
https://ncbi.nlm.nih.gov/pubmed/25800048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-01-622936
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