Biochemical Characterization of the Phosphatase Domain of the Tumor Suppressor PH Domain Leucine-Rich Repeat Protein Phosphatase

[Image: see text] PH domain leucine-rich repeat protein phosphatase (PHLPP) directly dephosphorylates and inactivates Akt and protein kinase C and is therefore a prime target for pharmacological intervention of two key signaling pathways, the phosphatidylinositol 3-kinase and diacylglycerol signalin...

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Hlavní autoři: Sierecki, Emma, Newton, Alexandra C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2014
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4072346/
https://ncbi.nlm.nih.gov/pubmed/24892992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500428j
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