Ceramide Promotes Apoptosis in Chronic Myelogenous Leukemia-Derived K562 Cells by a Mechanism Involving Caspase-8 and JNK

Ceramide is a sphingolipid that activates stress kinases such as p38 and c-JUN N-Terminal Kinase (JNK). Though Chronic Myelogenous Leukemia (CML) derived K562 cells resist killing by short chain C2-ceramide, we report here that longer chain C6-ceramide promotes apoptosis in these cells. C6-ceramide...

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Main Authors: Nica, Alina Felicia, Tsao, Chun Chui, Watt, Julie C., Jiffar, Tilahun, Kurinna, Svitlana, Jurasz, Paul, Konopleva, Marina, Andreeff, Michael, Radomski, Marek W., Ruvolo, Peter P.
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4072224/
https://ncbi.nlm.nih.gov/pubmed/18948750
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