Targeting PKC-Mediated Signal Transduction Pathways Using Enzastaurin to Promote Apoptosis in Acute Myeloid Leukemia-Derived Cell Lines and Blast Cells

Recent studies in acute myeloid leukemia (AML) suggest activation of pro-proliferative signaling cascades including those mediated by protein kinase C (PKC) represent a poor prognostic factor for patients. The classical PKC isoforms α and β generally support survival signaling and have emerged as im...

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Hlavní autoři: Ruvolo, Peter P., Zhou, Liran, Watt, Julie C., Ruvolo, Vivian R., Burks, Jared K., Jiffar, Tilahun, Kornblau, Steven, Konopleva, Marina, Andreeff, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3394435/
https://ncbi.nlm.nih.gov/pubmed/21360576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.23090
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