Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia

The mitogen-activated protein kinase (MAPK) pathway regulates growth and survival of many cell types, and its constitutive activation has been implicated in the pathogenesis of a variety of malignancies. In this study we demonstrate that small-molecule MEK inhibitors (PD98059 and PD184352) profoundl...

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Main Authors: Milella, Michele, Kornblau, Steven M., Estrov, Zeev, Carter, Bing Z., Lapillonne, Hélène, Harris, David, Konopleva, Marina, Zhao, Shourong, Estey, Elihu, Andreeff, Michael
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2001
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC200930/
https://ncbi.nlm.nih.gov/pubmed/11560954
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