Marine and Semi-Synthetic Hydroxysteroids as New Scaffolds for Pregnane X Receptor Modulation

In recent years many sterols with unusual structures and promising biological profiles have been identified from marine sources. Here we report the isolation of a series of 24-alkylated-hydroxysteroids from the soft coral Sinularia kavarattiensis, acting as pregnane X receptor (PXR) modulators. Star...

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Main Authors: Sepe, Valentina, Di Leva, Francesco Saverio, D’Amore, Claudio, Festa, Carmen, De Marino, Simona, Renga, Barbara, D’Auria, Maria Valeria, Novellino, Ettore, Limongelli, Vittorio, D’Souza, Lisette, Majik, Mahesh, Zampella, Angela, Fiorucci, Stefano
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4071567/
https://ncbi.nlm.nih.gov/pubmed/24871460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md12063091
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