CIIA prevents SOD1(G93A)-induced cytotoxicity by blocking ASK1-mediated signaling

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease with higher selectivity in degeneration of motor neurons. However, the molecular mechanism by which the ALS-linked mutants of human superoxide dismutase 1 (SOD1) gene induce neurotoxicity remains obscure yet. Here, we sh...

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Bibliographic Details
Main Authors: Lee, Jae Keun, Hwang, Sang Gil, Shin, Jin Hee, Shim, Jaekyung, Choi, Eui-Ju
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2014
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4071562/
https://ncbi.nlm.nih.gov/pubmed/25018698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00179
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