Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension

Abstract. In the present study, we tested the hypothesis that chronic inflammation and oxidative/nitrosative stress induce caveolin 1 (Cav-1) degradation, providing an underlying mechanism of endothelial cell activation/dysfunction and pulmonary vascular remodeling in patients with idiopathic pulmon...

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Detalhes bibliográficos
Main Authors: Bakhshi, Farnaz R., Mao, Mao, Shajahan, Ayesha N., Piegeler, Tobias, Chen, Zhenlong, Chernaya, Olga, Sharma, Tiffany, Elliott, W. Mark, Szulcek, Robert, Bogaard, Harm Jan, Comhair, Suzy, Erzurum, Serpil, van Nieuw Amerongen, Geerten P., Bonini, Marcelo G., Minshall, Richard D.
Formato: Artigo
Idioma:Inglês
Publicado em: University of Chicago Press 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4070841/
https://ncbi.nlm.nih.gov/pubmed/25006397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/674753
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