Injury-Induced Shedding of Extracellular Vesicles Depletes Endothelial Cells of Cav-1 (Caveolin-1) and Enables TGF-β (Transforming Growth Factor-β)–Dependent Pulmonary Arterial Hypertension

OBJECTIVE—: To determine whether pulmonary arterial hypertension is associated with endothelial cell (EC)–Cav-1 (caveolin-1) depletion, EC-derived extracellular vesicle cross talk with macrophages, and proliferation of Cav-1 depleted ECs via TGF-β (transforming growth factor-β) signaling. APPROACH A...

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Udgivet i:Arterioscler Thromb Vasc Biol
Main Authors: Oliveira, Suellen D.S., Chen, Jiwang, Castellon, Maricela, Mao, Mao, Raj, J. Usha, Comhair, Suzy, Erzurum, Serpil, Silva, Claudia L.M., Machado, Roberto F., Bonini, Marcelo G., Minshall, Richard D.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7297129/
https://ncbi.nlm.nih.gov/pubmed/30943774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.118.312038
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