Nitric oxide–dependent Src activation and resultant caveolin-1 phosphorylation promote eNOS/caveolin-1 binding and eNOS inhibition

Endothelial nitric oxide synthase (eNOS)–mediated NO production plays a critical role in the regulation of vascular function and pathophysiology. Caveolin-1 (Cav-1) binding to eNOS holds eNOS in an inactive conformation; however, the mechanism of Cav-1–mediated inhibition of activated eNOS is unclea...

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Detalhes bibliográficos
Main Authors: Chen, Zhenlong, Bakhshi, Farnaz R., Shajahan, Ayesha N., Sharma, Tiffany, Mao, Mao, Trane, Andy, Bernatchez, Pascal, van Nieuw Amerongen, Geerten P., Bonini, Marcelo G., Skidgel, Randal A., Malik, Asrar B., Minshall, Richard D.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315804/
https://ncbi.nlm.nih.gov/pubmed/22323292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-09-0811
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