Nitric oxide–dependent Src activation and resultant caveolin-1 phosphorylation promote eNOS/caveolin-1 binding and eNOS inhibition

Endothelial nitric oxide synthase (eNOS)–mediated NO production plays a critical role in the regulation of vascular function and pathophysiology. Caveolin-1 (Cav-1) binding to eNOS holds eNOS in an inactive conformation; however, the mechanism of Cav-1–mediated inhibition of activated eNOS is unclea...

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Bibliografski detalji
Glavni autori: Chen, Zhenlong, Bakhshi, Farnaz R., Shajahan, Ayesha N., Sharma, Tiffany, Mao, Mao, Trane, Andy, Bernatchez, Pascal, van Nieuw Amerongen, Geerten P., Bonini, Marcelo G., Skidgel, Randal A., Malik, Asrar B., Minshall, Richard D.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 2012
Teme:
Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315804/
https://ncbi.nlm.nih.gov/pubmed/22323292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-09-0811
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