Nitric oxide–dependent Src activation and resultant caveolin-1 phosphorylation promote eNOS/caveolin-1 binding and eNOS inhibition

Endothelial nitric oxide synthase (eNOS)–mediated NO production plays a critical role in the regulation of vascular function and pathophysiology. Caveolin-1 (Cav-1) binding to eNOS holds eNOS in an inactive conformation; however, the mechanism of Cav-1–mediated inhibition of activated eNOS is unclea...

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Auteurs principaux: Chen, Zhenlong, Bakhshi, Farnaz R., Shajahan, Ayesha N., Sharma, Tiffany, Mao, Mao, Trane, Andy, Bernatchez, Pascal, van Nieuw Amerongen, Geerten P., Bonini, Marcelo G., Skidgel, Randal A., Malik, Asrar B., Minshall, Richard D.
Format: Artigo
Langue:Inglês
Publié: The American Society for Cell Biology 2012
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315804/
https://ncbi.nlm.nih.gov/pubmed/22323292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-09-0811
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