Treg cells expressing the co-inhibitory molecule TIGIT selectively inhibit pro-inflammatory Th1 and Th17 cell responses

Foxp3(+) T regulatory (Treg) cells regulate immune responses and maintain self-tolerance. Recent work shows that Treg cells are comprised of many subpopulations with specialized regulatory functions. Here we identified Foxp3(+) T cells expressing the co-inhibitory molecule TIGIT as a distinct Treg c...

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Détails bibliographiques
Auteurs principaux: Joller, Nicole, Lozano, Ester, Burkett, Patrick R., Patel, Bonny, Xiao, Sheng, Zhu, Chen, Xia, Junrong, Tan, Tze G., Sefik, Esen, Yajnik, Vijay, Sharpe, Arlene H., Quintana, Francisco J., Mathis, Diane, Benoist, Christophe, Hafler, David A., Kuchroo, Vijay K.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4070748/
https://ncbi.nlm.nih.gov/pubmed/24745333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.02.012
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