Treg cells expressing the co-inhibitory molecule TIGIT selectively inhibit pro-inflammatory Th1 and Th17 cell responses

Foxp3(+) T regulatory (Treg) cells regulate immune responses and maintain self-tolerance. Recent work shows that Treg cells are comprised of many subpopulations with specialized regulatory functions. Here we identified Foxp3(+) T cells expressing the co-inhibitory molecule TIGIT as a distinct Treg c...

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Detalhes bibliográficos
Main Authors: Joller, Nicole, Lozano, Ester, Burkett, Patrick R., Patel, Bonny, Xiao, Sheng, Zhu, Chen, Xia, Junrong, Tan, Tze G., Sefik, Esen, Yajnik, Vijay, Sharpe, Arlene H., Quintana, Francisco J., Mathis, Diane, Benoist, Christophe, Hafler, David A., Kuchroo, Vijay K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4070748/
https://ncbi.nlm.nih.gov/pubmed/24745333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.02.012
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