Free IL-12p40 Monomer is a Polyfunctional Adapter for Generating Novel IL-12-Like Heterodimers Extracellularly

IL-12p40 partners with the p35 and p19 polypeptides to generate the heterodimeric cytokines IL-12 and IL-23 respectively. These cytokines play critical and distinct roles in host defense. The assembly of these heterodimers is thought to take place within the cell, resulting in the secretion of fully...

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Hauptverfasser: Abdi, Kaveh, Singh, Nevil J., Spooner, Eric, Kessler, Benedikt M., Radaev, Sergei, Lantz, Larry, Xiao, Tsan Sam, Matzinger, Polly, Sun, Peter D., Ploegh, Hidde L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4070439/
https://ncbi.nlm.nih.gov/pubmed/24821971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400159
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