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LPS Activated Dendritic cells: “Exhausted” or alert and waiting? DCs: “Exhausted”, alerted or waiting?

LPS-activated DCs are thought to follow a set program in which they secrete inflammatory cytokines (such as IL-12) and then become refractory to further stimulation (i.e. “exhausted”). Here we show that mouse DCs do indeed lose their responsiveness to LPS, but nevertheless remain perfectly capable o...

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Autori principali: Abdi, Kaveh, Singh, Nevil J., Matzinger, Polly
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370068/
https://ncbi.nlm.nih.gov/pubmed/22561154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102868
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