Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis

The protein kinase activity of the DNA-PKcs (DNA-dependent protein kinase catalytic subunit) and its autophosphorylation are critical for DBS (DNA double-strand break) repair via NHEJ (non-homologous end-joining). Recent studies have shown that depletion or inactivation of DNA-PKcs kinase activity a...

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Autores principales: Douglas, Pauline, Ye, Ruiqiong, Trinkle-Mulcahy, Laura, Neal, Jessica A., De Wever, Veerle, Morrice, Nick A., Meek, Katheryn, Lees-Miller, Susan P.
Formato: Artigo
Lenguaje:Inglês
Publicado: Portland Press Ltd. 2014
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Original Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4069685/
https://ncbi.nlm.nih.gov/pubmed/24844881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20140051
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