Population Pharmacokinetics of Rifapentine and Desacetyl Rifapentine in Healthy Volunteers: Nonlinearities in Clearance and Bioavailability

Rifapentine is under active investigation as a potent drug that may help shorten the tuberculosis (TB) treatment duration. A previous rifapentine dose escalation study with daily dosing indicated a possible decrease in bioavailability as the dose increased and an increase in clearance over time for...

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Bibliographic Details
Main Authors: Savic, Radojka M., Lu, Yanhui, Bliven-Sizemore, Erin, Weiner, Marc, Nuermberger, Eric, Burman, William, Dorman, Susan E., Dooley, Kelly E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068478/
https://ncbi.nlm.nih.gov/pubmed/24614383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01918-13
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