Safety and Pharmacokinetics of Escalating Daily Doses of the Antituberculosis Drug Rifapentine in Healthy Volunteers

Rifapentine (RPT) is an antituberculosis drug that may shorten treatment duration when substituted for rifampin (RIF). The maximal tolerated daily dose of RPT and its potential for cytochrome 3A4 induction and autoinduction at clinically relevant doses are unknown. In this phase I, dose-escalation s...

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Main Authors: Dooley, KE, Bliven-Sizemore, EE, Weiner, M, Lu, Y, Nuermberger, EL, Hubbard, WC, Fuchs, EJ, Melia, MT, Burman, WJ, Dorman, SE
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837382/
https://ncbi.nlm.nih.gov/pubmed/22472995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2011.323
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