The Carboxyl-terminal Tail of Noxa Protein Regulates the Stability of Noxa and Mcl-1

The BH3-only protein Noxa is a critical mediator of apoptosis and functions primarily by sequestering/inactivating the antiapoptotic Bcl-2 family protein Mcl-1. Although Noxa is a highly labile protein, recent studies suggested that it is degraded by the proteasome in a ubiquitylation-independent ma...

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Detalhes bibliográficos
Main Authors: Pang, Xiaming, Zhang, Jingjing, Lopez, Hernando, Wang, Yushu, Li, Wenyang, O'Neill, Katelyn L., Evans, Jacquelynn J. D., George, Nicholas M., Long, Jianhong, Chen, Yi, Luo, Xu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067213/
https://ncbi.nlm.nih.gov/pubmed/24811167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.548172
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