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The Carboxyl-terminal Tail of Noxa Protein Regulates the Stability of Noxa and Mcl-1
The BH3-only protein Noxa is a critical mediator of apoptosis and functions primarily by sequestering/inactivating the antiapoptotic Bcl-2 family protein Mcl-1. Although Noxa is a highly labile protein, recent studies suggested that it is degraded by the proteasome in a ubiquitylation-independent ma...
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| Autors principals: | , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4067213/ https://ncbi.nlm.nih.gov/pubmed/24811167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.548172 |
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