MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment

Cells experiencing delays in mitotic progression are prone to undergo apoptosis unless they can exit mitosis before proapoptotic factors reach a critical threshold. Microtubule targeting agents (MTAs) arrest cells in mitosis and induce apoptotic cell death engaging the BCL2 network. Degradation of t...

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Bibliographic Details
Published in:Cell Death Differ
Main Authors: Haschka, Manuel D., Karbon, Gerlinde, Soratroi, Claudia, O’Neill, Katelyn L., Luo, Xu, Villunger, Andreas
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7370223/
https://ncbi.nlm.nih.gov/pubmed/32015503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-0503-6
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