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MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation

MCL1 has critical antiapoptotic functions and its levels are tightly regulated by ubiquitylation and degradation, but mechanisms that drive this degradation, particularly in solid tumors, remain to be established. We show here in prostate cancer cells that increased NOXA, mediated by kinase inhibito...

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Pubblicato in:eLife
Autori principali: Arai, Seiji, Varkaris, Andreas, Nouri, Mannan, Chen, Sen, Xie, Lisha, Balk, Steven P
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7297531/
https://ncbi.nlm.nih.gov/pubmed/32484436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.54954
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