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Perturbation of the Bcl-2 Network and an Induced Noxa/Bcl-xL Interaction Trigger Mitochondrial Dysfunction after DNA Damage

How most apoptotic stimuli trigger mitochondrial dysfunction remains to be resolved. We screened the entire Bcl-2 network for its involvement in DNA damage-induced apoptosis in HeLa cells. Although the anti-apoptotic member Bcl-xL served as a major suppressor, apoptosis initiated only when both Mcl-...

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Autors principals: Lopez, Hernando, Zhang, Liqiang, George, Nicholas M., Liu, Xiaoqiong, Pang, Xiaming, Evans, Jacquelynn J. D., Targy, Natalie M., Luo, Xu
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865346/
https://ncbi.nlm.nih.gov/pubmed/20223826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.086231
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