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ARF Induces Autophagy by Virtue of Interaction with Bcl-xl

The ARF tumor suppressor controls a well-described p53/Mdm2-dependent oncogenic stress checkpoint. In addition, ARF has recently been shown to localize to mitochondria, and to induce autophagy; however, this has never before been demonstrated for endogenous ARF, and the molecular basis for this acti...

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Detalhes bibliográficos
Main Authors: Pimkina, Julia, Humbey, Olivier, Zilfou, Jack T., Jarnik, Michal, Murphy, Maureen E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631963/
https://ncbi.nlm.nih.gov/pubmed/19049976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804705200
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