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Muscarinic acetylcholine receptor X-ray structures: potential implications for drug development

Muscarinic acetylcholine receptor antagonists are widely used as bronchodilating drugs in pulmonary medicine. The therapeutic efficacy of these agents depends on the blockade of M(3) muscarinic receptors expressed on airway smooth muscle cells. All muscarinic antagonists currently used as bronchodil...

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Main Authors: Kruse, Andrew C., Hu, Jianxin, Kobilka, Brian K., Wess, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065632/
https://ncbi.nlm.nih.gov/pubmed/24662799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coph.2014.02.006
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