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Alzheimer’s disease therapeutics targeted to the control of amyloid precursor protein translation: Maintenance of brain iron homeostasis

The neurotoxicity of amyloid beta (Aβ), a major cleavage product of the amyloid precursor protein (APP), is enhanced by iron, as found in the amyloid plaques of Alzheimer’s disease (AD) patients. By contrast, the long-known neuroprotective activity of APP is evident after α-secretase cleavage of the...

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Autori principali: Bandyopadhyay, Sanghamitra, Rogers, Jack T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4064675/
https://ncbi.nlm.nih.gov/pubmed/24513321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2014.01.032
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