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DNA DSB repair pathway choice: an orchestrated handover mechanism

DNA double strand breaks (DSBs) are potential lethal lesions but can also lead to chromosome rearrangements, a step promoting carcinogenesis. DNA non-homologous end-joining (NHEJ) is the major DSB rejoining process and occurs in all cell cycle stages. Homologous recombination (HR) can additionally f...

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Autori principali: Kakarougkas, A, Jeggo, P A
Natura: Artigo
Lingua:Inglês
Pubblicazione: The British Institute of Radiology. 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4064598/
https://ncbi.nlm.nih.gov/pubmed/24363387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1259/bjr.20130685
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